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MiR-369-5p inhibits the proliferation and migration of hepatocellular carcinoma cells by down-regulating HOXA13 expression.
Qian X, Wang Y, Hu W, Xu X, Gao L, Meng Y, Yan J. Qian X, et al. Tissue Cell. 2022 Feb;74:101721. doi: 10.1016/j.tice.2021.101721. Epub 2021 Dec 27. Tissue Cell. 2022. PMID: 34979376
Pearson correlation test was used to analyze the correlation between HOXA13 and miR-369-5p. The above assays were experimented again to investigate the effects of HOXA13 on biological activity and EMT of HCC cells. MiR-369-5p expression was down-regulated and HOX …
Pearson correlation test was used to analyze the correlation between HOXA13 and miR-369-5p. The above assays were experimented again …
The HOX gene network in hepatocellular carcinoma.
Cillo C, Schiavo G, Cantile M, Bihl MP, Sorrentino P, Carafa V, D' Armiento M, Roncalli M, Sansano S, Vecchione R, Tornillo L, Mori L, De Libero G, Zucman-Rossi J, Terracciano L. Cillo C, et al. Int J Cancer. 2011 Dec 1;129(11):2577-87. doi: 10.1002/ijc.25941. Epub 2011 May 30. Int J Cancer. 2011. PMID: 21626505 Free article.
HOXA13 is a determinant of gut primordia and posterior body structures. ...Thus, transcriptional and post-transcriptional HOXA13 deregulation is involved in HCC possibly through the mRNA nuclear export of eIF4E-dependent transcripts....
HOXA13 is a determinant of gut primordia and posterior body structures. ...Thus, transcriptional and post-transcriptional HOXA13 …
Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients.
Quagliata L, Matter MS, Piscuoglio S, Arabi L, Ruiz C, Procino A, Kovac M, Moretti F, Makowska Z, Boldanova T, Andersen JB, Hämmerle M, Tornillo L, Heim MH, Diederichs S, Cillo C, Terracciano LM. Quagliata L, et al. Hepatology. 2014 Mar;59(3):911-23. doi: 10.1002/hep.26740. Epub 2014 Jan 28. Hepatology. 2014. PMID: 24114970 Free PMC article.
We previously described HOX genes deregulation to be involved in hepatocarcinogenesis. Indeed, we observed the marked up-regulation of HOXA13 in HCC. Here, by correlating clinicopathological and expression data, we demonstrate that the levels of HOTTIP and HOXA13 ar …
We previously described HOX genes deregulation to be involved in hepatocarcinogenesis. Indeed, we observed the marked up-regulation of HO …
Hepatitis B Virus DNA Polymerase Restrains Viral Replication Through the CREB1/HOXA Distal Transcript Antisense RNA Homeobox A13 Axis.
Zhao X, Fan H, Chen X, Zhao X, Wang X, Feng Y, Liu M, Li S, Tang H. Zhao X, et al. Hepatology. 2021 Feb;73(2):503-519. doi: 10.1002/hep.31284. Hepatology. 2021. PMID: 32314410
Virological experiments showed that HOTTIP significantly suppresses the generation of hepatitis B viral surface antigen, hepatitis B viral e antigen and HBV replication. Homeobox A13 (HOXA13), a downstream factor of HOTTIP, was found to bind to HBV enhancer I and X promoto …
Virological experiments showed that HOTTIP significantly suppresses the generation of hepatitis B viral surface antigen, hepatitis B viral e …
MiRNA-192 [corrected] and miRNA-204 Directly Suppress lncRNA HOTTIP and Interrupt GLS1-Mediated Glutaminolysis in Hepatocellular Carcinoma.
Ge Y, Yan X, Jin Y, Yang X, Yu X, Zhou L, Han S, Yuan Q, Yang M. Ge Y, et al. PLoS Genet. 2015 Dec 28;11(12):e1005726. doi: 10.1371/journal.pgen.1005726. eCollection 2015 Dec. PLoS Genet. 2015. PMID: 26710269 Free PMC article.
Besides the known targets (multiple 5' end HOX A genes, i.e. HOXA13), glutaminase (GLS1) was identified as a potential downstream target of the miR-192/-204-HOTTIP axis in HCC. ...
Besides the known targets (multiple 5' end HOX A genes, i.e. HOXA13), glutaminase (GLS1) was identified as a potential downstream tar …